Infliximab, known commercially as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb) that targets tumor necrosis factor-alpha (TNF).
In studies conducted, a significant number of patients (30-40%) who did not respond to anti-TNF treatment were identified.
Current methods for monitoring infliximab are almost exclusively based on immunological tests.
In this study, the amount of infliximab was more selectively determined by LC-MS / MS using nSMOL proteolysis targeting the Fab CDR region.
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