Shimadzu Corporation

LCMS-2020 Liquid Chromatography Mass Spectrometer (LCMS)

Building an LC/MS system that employs an MS as an LC detector can effectively reduce the limitations of LC analysis. In addition to this, reducing those limitations to the greatest extent possible requires an MS that can handle ultra high speed analysis.
 
To detect both positive and negative ions, analysis is performed while switching between the positive and negative ionization modes. The LCMS-2020 adopts a high-voltage power supply featuring novel technology (patent pending) to achieve an ultra-fast polarity switching time of just 15 ms.

Building an LC/MS system that employs an MS as an LC detector can effectively reduce the limitations of LC analysis. In addition to this, reducing those limitations to the greatest extent possible requires an MS that can handle ultra high speed analysis.
 
To detect both positive and negative ions, analysis is performed while switching between the positive and negative ionization modes. The LCMS-2020 adopts a high-voltage power supply featuring novel technology (patent pending) to achieve an ultra-fast polarity switching time of just 15 ms.
 
Accurate mass analysis of sharp chromatographic peaks obtained by UFLC requires ultra-fast MS detection capabilities. The LCMS-2020 offers UFswitching for rapid switching between the positive and negative ionization modes and UFscanning for ultra-fast scan measurements to capture the sharpest UFLC peaks.
 
UFscanning system ,which promises 15,000 u/sec. Scan speed, Controls the voltage applied to the Quadrupole according to the scan speed and m/z. This new technology (patent pending) maintains resolution and achieves high ion transmittance even at high scanning speeds.
 
In order to check the toughness of the LCMS-2020 against dirty samples, plasma samples simply precipitated with only acetonitrile were injected 2,500 times over 10 days (1µL volume per injection). Excellent reproducibility of peak area was demonstrated and its RSD was 2.26%.
 
In-source CID (collision-induced dissociation) is effective for confirming the molecular weight of synthetic compounds and for the quantification of impurities. Using in-source CID allows the generation of fragment ions. The multi-sequence mode permits several other methods within a single analysis, such as CID, positive/negative ion switching modes, and SCAN/SIM modes.
 
The desolvation line (DL) that introduces the sample from the ion source into the vacuum can be installed and uninstalled without breaking the vacuum, which dramatically enhances ease-of-maintenance.

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