Shimadzu Corporation

Nexera XR Modular UHPLC System Dual pump, 4 gradients, 660 bar

The balance between an appropriately small particle-sized column media and the length of a column is an important factor to improving column performance. For true high-resolution analysis, a number of conditions must be met. These include finding a balance between increased column pressure and a smaller particle size; developing a system durable enough to handle the pressure; using a detector with high sensitivity and a wide dynamic range; and optimizing the flow path for minimal diffusion.

Prominence UFLCXR provides high-pressure endurance by utilizing the technological advancements and knowledge developed during the ongoing refinement of the Prominence series. Our aim has been to make high-speed analysis compatible with high resolution, not simply to perform high-speed analysis with a smaller particle-sized column. The Prominence UFLCXR achieves this goal.

Excellent reproducibility and minimal carryover, two fundamental performance features of an HPLC, are the most important factors among the specifications required for an analytical system. Shimadzu has surged ahead of other vendors in wrestling with these two issues through the development of a high-performance solvent delivery pump, an autosampler that delivers high reproducibility from a small injection volume, an injection mechanism for near-zero carryover, and other technological excellence. The Prominence UFLCXR proves this excellence by reconciling high performance and high resolution with sufficient performance for high-sensitivity analysis using both a UV detector and a liquid chromatograph mass spectrometer

The balance between an appropriately small particle-sized column media and the length of a column is an important factor to improving column performance. For true high-resolution analysis, a number of conditions must be met. These include finding a balance between increased column pressure and a smaller particle size; developing a system durable enough to handle the pressure; using a detector with high sensitivity and a wide dynamic range; and optimizing the flow path for minimal diffusion.

  • Baseline stability is affected by numerous factors, including the performance of the pump, oven, detector, and other components. The photodiode array detector and the fluorescence detector offer world-leading sensitivity. Equipped with a temperature control function to suppress the effects of room temperature fluctuations, these detectors achieve excellent baseline stability and reproducibility.
  • Low carryover is essential for high-sensitivity LC/MS/MS systems. Shimadzu autosamplers have been engineered with this in mind. The structure of the needle seal and the materials for the parts in contact with fluids have been thoroughly revised to keep sample component adsorption to the absolute minimum. As a result, no carryover has been detected even for substances prone to adsorption.
  • The Nexera XR is equipped with a high-performance scale to accurately measure samples, achieving excellent reproducibility, even for trace-quantity injections.
  • Nexera XR accepts both standard HPLC columns and 2 μm to 3 μm high-speed, high-separation columns. As a standard UHPLC model, it supports the speed-up of existing methods.

  • İlaç Analizleri Hakkında - Shimadzu Journal Sayı 3

    • Insights from our customer Professor Alexander Arnold from the Milwaukee Institute for Drug Discovery at the University of Wisconsin-Milwaukee
    • The collaboration with Mitsubishi Tanabe Pharma Corporation, Japan for development of pharmaceutical products using Imaging Mass Spectrometry: iMScope TRIO
    • Metabolic Studies of Drug Candidates for Neurological Disorders and Asthma Based on GABAA Receptor Subtype Selective Ligands using Mass Spectrometry
    • Utility of High-resolution MALDI imaging in Drug Discovery: Histological Distribution of Gentamicin in Proximal Renal Tubules of Rats
    • And many more ...

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