AB SCIEX TOF/TOF™ 5800
LC/MS/MS System
The AB SCIEX TOF/TOF™ 5800 System provides the fastest and most confident path to the identification and relative quantitation of proteins. The system’s unmatched speed and sensitivity make it the ideal platform for biomarker discovery, MALDI mass spectrometry imaging, and protein identification. More than 10X faster data acquisition with new 1KHz laser and DynamicExit™ algorithm Unique OPtiBeam™ on-axis laser irradiation increases sensitivity in both MS and MS/MS modes by 10x over systems without an on-axis laser Maximum up-time and throughput by continuously heating of the source mirror and user programmable source mirror cleaning Improved resolution with new reflectron mirror design and 1000 MHz digitizer High-resolution precursor ion selection with novel timed-ion selector More than 10X faster acquisition The new 1 kHz laser provides lightning-fast ionization, and the innovative DynamicExit algorithm provides highest-confidence IDs with the fewest number of laser shots. Now, LC MALDI TOF/TOF system analysis speed rivals that of ESI/MS/MS. Easier to Use The new EasyAccess™ Wizard provides a single-page interface that quickly guides the user through setting up acquisition parameters. Simple to use but powerful, ProteinPilot™ Software 3.0 is complemented by application-specific software to ensure that getting meaningful results is fast and easy. Better Performance The new EasyAccess Wizard provides a single-page interface that quickly guides the user through setting up acquisition parameters. Simple to use but powerful, ProteinPilot™ Software 3.0 is complemented by application-specific software to ensure that getting meaningful results is fast and easy. Longer continuous run times A user-programmable routine cleans the MALDI source to eliminate contamination due to matrix deposits, and the heated source mirror is continually cleaned. There’s no more need to break your experimental sequence to keep the instrument running optimally. Ideal system for iTRAQ® reagents The 5800 System is designed to provide the highest sensitivity and most reproducible results from isobaric tagging workflows, such as iTRAQ® Reagents 8-plex. No modifications or add-ons are required to achieve optimal results. See information that you’ve been missing Electrospray mass spectrometers only give you part of the picture. MALDI TOF/TOF data is a perfect compliment to ESI data for more comprehensive, in-depth identification and relative quantitation of proteins in complex samples. Get the greatest depth of coverage with the LC MALDI workflow The LC MALDI workflow separates the time constraints of LC from the mass analysis. With your chromatographic run "stored" on a MALDI plate, you can spend as much time as required to get the maximum information from a given region or time point.


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4800 Plus
MALDI TOF/TOF™ Analyzer

The 4800 Plus MALDI TOF/TOF™ Analyzer is the next generation of tandem time-of-flight MS/MS systems, providing the highest level of protein coverage, throughput, and confidence in quantitative proteomic analysis. The analyzer combines all of the advantages of MALDI in a flexible, easy-to-use, ultra-high-performance mass spectrometer with all the advanced capabilities of ProteinPilot™ v3.0 software.

Product Description

• Ideal system for protein biomarker discovery, providing simultaneous identification and quantitation of up to 8 samples at a time (8-plex workflow) using iTRAQ™ Reagents.
• Fully supports LC MALDI workflows, allowing you to mass analyze without the time constraints of LC.
• Compatible with ProteinPilot v3.0 software for increased protein coverage and confidence in identification and quantitation results.
• OptiBeam™ on-axis laser provides ten times greater sensitivity to identify and quantitate low-abundance proteins in complex biological samples.
• High-resolution precursor ion selection, enabled by the QuanTIS™ precursor selector, lets you detect and identify peptides that other systems miss and makes it easier for you to interpret your data by simplifying MS/MS spectra.
• Simple experiment setup and fast mass analysis maximizes laboratory productivity.
• High-energy, information-rich fragmentation patterns unavailable on other instrument platforms enable you to analyze carbohydrates, lipids, and other biological components.
• Improved on-board computing capabilities handles large scale protein discovery studies with faster processing and automated data backup.
• Identify and Quantitate Putative Protein Biomarkers with Confidence The 4800 Plus MALDI TOF/TOF analyzer offers a new level of sensitivity for identifying and quantifying low abundance putative protein biomarkers. Fully compatible with new iTRAQ™ Reagents – 8plex, the 4800 analyzer provides the most direct path to protein biomarker discovery. An expanded dynamic range enables high confidence identification and quantitation of low-level putative protein biomarkers in complex matrices. Powerful, easy-to-use ProteinPilot v3.0 Software provides simplified quantitation, and automated workflows to get you more quickly from discovery to validation.
• The Only MALDI TOF/TOF Analyzer with On-Axis Laser IrradiationThe 4800 Plus Analyzer is the only commercially available MALDI TOF/TOF mass spectrometer with on-axis laser irradiation, enabling sensitivity in the attomole range. Proprietary source modeling algorithms enable low ppm mass detection across the MALDI plate.
• Expand Workflows, Increase Throughput Get the speed, stability, and reliability you need to expand your current experimental workflows and add statistical significance to your experimental results. Quickly and easily increase throughput using automation features that allow you to rapidly and confidently collect the MS/MS spectra that really matter and not waste valuable resources acquiring and evaluating those that don't.

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