Maximizing Reliability, Minimizing Down Time

(1) Absorbance Detector SPD-40 / SPD-40V and Photodiode Array Detector SPD-M40

• Temperature control improves performance stability.
• Analytical data is linked to information about consumables to ensure traceability.

(2) Solvent Delivery Unit LC-40 Series

• Auto-diagnostics to detect problems during analysis, and an auto-recovery function.
• Reduces space requirements with a dual solvent delivery system.

(3) Autosampler SIL-40 Series / PLATE CHANGER

• The injection speed is twice as fast as previous models, shorte ning multi-analyte processing times.
• Can perform continuous analysis on up to 44 microtiter plates.
• High reproducibility and ultra-low carryover for micro-volume injections.
• Automated sample preparation functions such as diluting samples, adding internal standards, and performing derivatization reactions, reduce labor.

(4) Mobile Phase Monitor MPM-40

• Reservoir tray weight sensors monitor the remaining mobile phase in real time.

(5) System Controller SCL-40, CBM-40

• Supports remote monitoring via a smart device.
• Mobile phases can be purged and baselines checked easily via the touch panel.

• Injection count, analysis pressure, and other column information is automatically managed.
• Easy column attach/detach mechanism prevents peak broadening.
• LabSolutions monitors column degradation level based on usage history.

Auto-Diagnostics and Recovery

In rare cases, air bubbles can form in the mobile phase and cause problems if inhaled into the pump. Nexera has the ability to monitor baseline changes and pressure fluctuations to check for abnormalities.
When it detects an unusual fluctuation, it can automatically pause the analysis, purge the flow path, and restart analysis once it has confirmed recovery to normal pressure.

FlowPilot Protects Chromatography Columns

HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.

Mobile Phase Levels Measured in Real Time

Reservoir tray weight sensors (optional) can be used to monitor the volume of mobile phase or autosampler rinse solution in up to twelve containers. The containers can also be checked remotely from a smart device.
You will no longer need to worry about running out of mobile phase mid-analysis, because the device will notify you before starting the run if the volume remaining is too low.

Remote Monitoring and Integrated Lab Management

Reliably Track Column Usage

Columns used in analysis need to be traceable to investigate any influence they may have on results. With the Column Management Device (optional), each column is recognized by an individual ID, and stats such as pressure and injection number are automatically recorded in the database and linked to each measurement data file. The device can be linked to all columns regardless of their brand or type. The condition of a column can be checked directly with the column management software, so that you can start analysis without having to test column performance in advance. *To make use of this feature, a CMD compatible with the Nexera series and LabSolutions DB/CS are required.

Check Chromatograms Online

View the operating status of instruments from a web browser using a smart device. This allows you to confirm parameters such as oven temperature and pump status directly from the web, and to monitor chromatograms in real time without returning to the lab. In addition, SHIMADZU LabTotal™ Smart Service Net (optional) saves operating data from your instruments in a cloud server. Error information, including the date and time the errors occurred, can be sent via email.



 

Automating Workflow, Maximizing Throughput

Analysis Cycle Time Less Than 10 Seconds

The SIL-40 autosampler can process the entire injection cycle time in as little as seven seconds, twice as fast as the previous model. In addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically increase analysis throughput.

Remote Instrument Maintenance Ensures Stable Operation

Each Nexera component automatically transfers the status of consumable parts, the traceability information of consumable parts after shipment from the factory, and various logs and error information to the SHIMADZU LabTotal Smart Service Net cloud system. Using this information, the system recommends the timing for consumable part replacement. Problems can be diagnosed remotely by Shimadzu service engineers. This means the system can be maintained in optimal condition and equipment management costs can also be reduced.

High-Sensitivity Impurity Analysis

The SPD-M40 detector achieves an extremely high level of sensitivity and linearity (up to 2.5 AU). This allows quantitation of very lowconcentration impurities even in high-concentration samples. The UV cut-off filter installed in the detector prevents sample degradation due to UV light, helping to maintain good linearity at low concentrations.

Improvement of Quantitative Performance using UV Cut-Off Filter on SPD-M40

The UV cut-off filter resulted to be useful for quantitative determination of components that are easily degraded by wavelengths in the UV range, particularly improving quantitation accuracy in the low concentration range.

Ultra-low Carryover

The Nexera boasts ultra-low carryover, even on a high-sensitivity LC/MS/MS. This reduces time spent on rinsing, resulting in a shorter overall analysis time.

Compact and Inventive

Space-Saving Design

The Nexera frees up bench space with a　compact design two thirds the size of　Shimadzu's previous model.

Energy-Saving Standby Mode

The Nexera uses over 80% less electricity when in standby mode, significantly reducing running costs and supporting an environmentally-friendly lab

Dual Injection Enables Simultaneous Analysis

Injection ports for two separate flow paths can be installed, allowing two different types of analysis (such as analysis of amino acids, organic acids or vitamins) to be performed using one system.

Intuitive Touch Panel

The large LCD touch panel on the SCL-40 system controller removes the need for a PC. As well as controlling the instrument and checking the analysis status, you can monitor chromatograms directly from the display. Note: If you prefer to link the system to a PC, the touch panel feature can be turned off. Please inform the service staff during system installation.

ANALYTICAL INTELLIGENCE 

Automated support functions using digital technology such as M2M, IoT and Artificial Intelligence (AI), providing higher productivity and maximum reliability.
It allows a system to monitor and diagnose itself, handle any issues during data collection without user input, and automatically pretend to be run by an expert.
It supports the capture of high quality, reproducible data regardless of operator skill level for both routine and demanding applications.