Life Science and biotechnology include research areas such as proteomics, genomics and metabolomics. In addition, pharmaceutical companies require analytical and testing instruments that meet the needs of the modern age by helping to manufacture safe pharmaceuticals in compliance with IQ/OQ requirements and other applicable regulations.

We are actively supporting life science and biotech research as well as pharmaceutical R&D and Quality Control laboratories in in wide variety of areas such as impurity analysis, heavy metals, active pharmaceutical ingredients (API), organic solvents and residual solvent analysis, cleaning validation, solubility, crystal structure, stability testing, stereoisomer analysis, friability, viscosity, density measurements, contamination control and sterilisation solutions for GMP areas, life science research areas such as proteomics, genomics and metabolomics.
 

Field Applications and Analysis Products
Drug Discovery Basic drug discovery and research MALDI-TOFMS, LCMSMS, GCMS, IMScope, MultiNA

Low-Molecular Weight Pharmaceuticals

Drug Discovery and Chemistry 
(Synthesis and Purification)
Drug discovery and chemical research PrepLC, SALD
Synthesis HPLC, LCMSMS
Impurities analysis Co-Sense, LCMS-IT-TOF, ICP
CMC (Development, Formulation, Production QA/QC) Analytical method development HPLC, GC
Pharmaceutical formulation inversitgations Thermal Analyzers, SALD
Impurity analysis Co-Sense, LCMS-IT-TOF, HS-GC, HS-GCMS
Elution tests HPLC, UV
Biopharmaceuticals Drug Discovery Structural analysis MALDI-TOFMS, HPLC, LCMS-IT-TOF
Culture solution analysis

UF-Amino Station

CMC (Development, Formulation, Production QA/QC) Analytical method development HPLC, PPSQ, SALD
Farmakokinetics, Metabolomix, Safety PK/TK ADME HPLC, LCMSMS, IMScope
Production Cleaning validation TOC, UV, HPLC

| Pharmaceutical & Life Science Application Areas |

 

Life science research (genomics, proteomics, metabolomics, glycomics)

 

Drug discovery (biomarker discovery, screening and synthesis);

 

Pharmaceutical development (pre-clinical, toxicology, pharmacology, formulation, process)

 

Drug metabolism (ADME, DMPK)

 

Production and QA/QC (quality control and quality assurance) process

 

Biopharmaceuticals (protein characterization, impurity analysis)

 

OTC drugs/natural products

 
  • Aplikasyon 3

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

  • Aplikasyon 1

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

  • Aplikasyon 2

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum

  • Quantitation of monoclonal antibody infliximab in human plasma by LC-MS/MS using Fab-selective limited proteolysis nSMOL technology

    Infliximab, known commercially as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb) that targets tumor necrosis factor-alpha (TNF).
    In studies conducted, a significant number of patients (30-40%) who did not respond to anti-TNF treatment were identified.

    Instrument: LCMS-8060 Liquid Chromatography Mass Spectrometer (LCMSMS)

  • Povidone, Formic Acid Test (USP/EP/JP)

    Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It additionally acts as a disintegrant and tablet binder.

    The revision to the harmonized standard for Povidone has been approved and Formic Acid in Povidone is now required to be measured.

  • Incorporation of a Novel, Automated Scratch Tool and Kinetic Label-Free Imaging to Perform Wound Healing Assays

    The wound healing or "scratch" assay is one of the most highly used in vitro methods to monitor and quantify collective cell migration.

  • Pharmaceuticals and Human Science - Shimadzu Journal Cilt 2, Sayı 1

    Pharmaceuticals and Human Science: This issue focuses on Pharmaceuticals and Human Science, and contains such articles as follows:

    • An interview with Professor van Breemen, who is studying medicinal properties of natural products at the University of Illinois, College of Pharmacy, in Chicago, using advanced mass spectrometry

    • Professor van Breemen's latest work of the effect of human exposure to bisphenol A in the environment

    • Two interviews with Japanese pharmaceutical companies about Shimadzu's new technologies i-PDeA and i-DReC and technical reports of each technology

    • In addition, it contains information on other applicable topics, as well as the latest news and applications.

  • ProteaseTag ™ Active NE Immunoassay: A Rapid Test for the Quantification of Neutrophil Elastas Levels in Patients

    Oliver Carney, BMG LABTECH Ltd, Aylesbury, UK; Kelly Moffitt and Charlene Robb, ProAxsis, Belfast, Northern Ireland, 02/2016

    The neutrophil elastase is a biomarker of respiratory diseases such as cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). A simple, rapid and accurate test for neutrophil elastase levels in patient samples would be a significant medical benefit. Established methods do not specifically verify the presence of the enzyme leading to a high value of false positives. In this application note we show how to use the ProteaseTag™ Active Neutrophil Elastase Immunoassay from the company ProAxsis which is based in Northern Ireland. 

    The assay uses tags to specifically bind the enzyme of interest. Chromogenic detection is performed with the CLARIOstar® microplate reader which analysis the results and return qualified data automatically. 

    Protease levels can be determined in sputum sol, bronchoalveolar lavage, wound exudate or serum free cell culture.

  • İlaç Analizleri Hakkında - Shimadzu Journal Sayı 3

    • Insights from our customer Professor Alexander Arnold from the Milwaukee Institute for Drug Discovery at the University of Wisconsin-Milwaukee
    • The collaboration with Mitsubishi Tanabe Pharma Corporation, Japan for development of pharmaceutical products using Imaging Mass Spectrometry: iMScope TRIO
    • Metabolic Studies of Drug Candidates for Neurological Disorders and Asthma Based on GABAA Receptor Subtype Selective Ligands using Mass Spectrometry
    • Utility of High-resolution MALDI imaging in Drug Discovery: Histological Distribution of Gentamicin in Proximal Renal Tubules of Rats
    • And many more ...

  • Analysis of DNA Damage Size with LCMSMS

    The aim of this study was to investigate the relationship between significant antioxidative metabolism in mice and to demonstrate the extent of oxidative damage over 8-hydroxy-2-deoxyguanosine (8-OHdG).

    Instrument: LCMS-8040 Liquid Chromatography Mass Spectrometer (LCMSMS)

  • Determination of Genotoxic Impurities in Drug by 2D-LCMS

    Determination of genotoxic impurities in 2D-LCMSMS (Co-Sense) system.

    Instrument:  LCMS-8040 Liquid Chromatography Mass Spectrometer (LCMSMS)

  • Determination of Adhesion of Brass Starch to Aluminum Panels

    Determination of adhesion of brass starch with centrifugal force.

    Instrument: Hitachi Koki CS-FNX series / S110AT

  • Cleaning Validation in Pharmaceutical Industry with TOC

    In this study, a cleaning validation application for the pharmaceutical industry with Wet Chemical TOC Analyzer is included.

    Instrument: Shimadzu TOC-V WP Total Organic Carbon Analyzer