Shimadzu Corporation

LCMS-8050 Liquid Chromatograph Triple Quadrupole Mass Spectrometer (LCMSMS)

Continuing the evolution of Shimadzu's UF technology. Shimadzu introduces LCMS-8050 Triple Quadrupole Mass Spectrometer offering unparalleled measurement speed and high-sensitivity performance.

  • High sensitivity quantitation delivered at high speed
  • High speed scanning (UFscanning)
  • High sensitivity and Positive / Negative Ionization Switching Technology (UFswitching)
  • High sensitivity and high speed MRM (UF-MRM)
  • Patented ultra fast technologies (UFMS)
  • Method packages and databases (Pesticides, Forensic Tox, Veterinary, Met ID and more)

UFscanning

High-Sensitivity & High-Speed Scanning at 30,000 u/sec

Simultaneous Quantitative and Qualitative Analysis
Simultaneous High-Speed Screening of 12 Toxicological Drugs


The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step.

MRM Triggered Product Ion Scanning of a Mixture of 12 Benzodiazepines (1 ng/mL each)

UFswitching

High-Sensitivity & High-Speed Positive/Negative Ionization Switching in 5 msec

Just One Minute per Analysis
A Case Study Using High-Speed Positive/Negative Ionization Switching


When performing simultaneous positive/negative ion measurements of multiple components, the proper acquisition of sharp UHPLC peaks depends on rapid polarity switching. The LCMS-8050 minimizes losses due to polarity switching and ensures the collection of sufficient data points for even the narrow peaks obtained with UHPLC, recording accurate peak shapes and allowing excellent reproducibility.

UF-MRM

High-Sensitivity & High-Speed MRM at 555 ch/sec

Detect Target Compounds at Trace-Level Concentrations
Simultaneous Analysis of 29 Pesticides for Water Quality Analysis


The LCMS-8050 is capable of simultaneously acquiring 555 MRM transitions per second while maintaining accuracy and precision. Sufficient data points can be collected for quantitation ions, reference ions, and internal standard ions even in chromatographic regions with unresolved peaks. The high sensitivity of the LCMS-8050 allows for trace-level analysis, such as pesticides in drinking water, without the need for sample pre-concentration. This high sensitivity is maintained even when monitoring numerous MRM channels.

  • İlaç Analizleri Hakkında - Shimadzu Journal Sayı 3

    • Insights from our customer Professor Alexander Arnold from the Milwaukee Institute for Drug Discovery at the University of Wisconsin-Milwaukee
    • The collaboration with Mitsubishi Tanabe Pharma Corporation, Japan for development of pharmaceutical products using Imaging Mass Spectrometry: iMScope TRIO
    • Metabolic Studies of Drug Candidates for Neurological Disorders and Asthma Based on GABAA Receptor Subtype Selective Ligands using Mass Spectrometry
    • Utility of High-resolution MALDI imaging in Drug Discovery: Histological Distribution of Gentamicin in Proximal Renal Tubules of Rats
    • And many more ...

  • Taurine Analysis in Energy Drinks by LCMSMS

    In this study, LCMSMS uses taurine analysis, a sulfur-derived amino acid that is frequently used in energy drinks and is derived from semi-essential methionine and cysteine.

    Instrument: Shimadzu LCMS-8040 Liquid Chromatography Triple Quadrupole Mass Spectrometer


     

  • Pharmaceuticals and Human Science - Shimadzu Journal Cilt 2, Sayı 1

    Pharmaceuticals and Human Science: This issue focuses on Pharmaceuticals and Human Science, and contains such articles as follows:

    • An interview with Professor van Breemen, who is studying medicinal properties of natural products at the University of Illinois, College of Pharmacy, in Chicago, using advanced mass spectrometry

    • Professor van Breemen's latest work of the effect of human exposure to bisphenol A in the environment

    • Two interviews with Japanese pharmaceutical companies about Shimadzu's new technologies i-PDeA and i-DReC and technical reports of each technology

    • In addition, it contains information on other applicable topics, as well as the latest news and applications.

  • Determination of Chemical Compounds with Perfluor Group (PFOSs) in Textile, Leather and Paper Materials by LCMSMS System

    In this study, qualitative and quantitative analysis of Chemical Compounds with Perflor Group (PFOSs) in textile, leather and paper materials was performed by using LCMSMS system.

    Instrument: LCMS-8030 Liquid Chromatography Mass Spectrometer (LCMSMS)
     

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