Shimadzu Corporation

MALDI-7090 MALDI TOF-TOF Mass Spectrometer

The MALDI-7090TM is targeted for proteomics and tissue imaging. It combines Shimadzu’s extensive MALDI TOF-TOF mass spectrometry expertise with novel patented technology to provide ultimate performance in identification and structural characterization of biomolecules.

MALDI-7090 sets a new benchmark in MALDI TOF-TOF design

  • Market leading MS/MS resolution
  • Proprietary solid state UV laser technology
  • Ultra Fast acquisition speed in MS and MS/MS
  • Integrated 10 plate loader
  • Newly designed MALDI SolutionsTM software

Ionization Source

  • Variable ion extraction energy (linear up to +/-20 kV, reflectron up to +/-20 kV)
  • Positive and negative ion operation, as standard, through software selection
  • Unique wide-bore ion optics to minimize source contamination
  • TrueClean™ – software-driven UV laser-based source cleaning to reduce the need for maintenance

Laser

  • Solid-state ultra fast UV laser
  • True 2 kHz laser for both MS and MS/MS acquisitions
  • 355 nm wavelength
  • Variable focus from 10 μm to >100 μm
  • Maximum pulse rate 2 kHz (2000 shots per second)
  • Variable pulse rate from 1 Hz to 2000 Hz

Analyzer

  • Linear flight tube of 2.1 m drift length
  • Reflectron effective path length: 4.1 m
  • Vacuum maintained by 2 turbomolecular pumps with rotary backing
  • Unique curved-field reflectron system permitting 20 keV laboratory frame energy CID without reacceleration
  • Beam blanking to deflect unwanted high intensity signals e.g. matrix ions
  • Unique high resolution dual wire-grid ion gate allowing isolation of adjacent precursor ions
  • Collision cell (20 keV high energy CID MS/MS) fully optimized forfragmentation efficiency and ultimate sensitivity
  • Software-controlled helium gas introduction for high-energy CID MS/MS
  • ASDF™ – Axial Spatial Distribution Focussing – for 10 000 resolution of MS/MS fragment ions

Detectors

  • Linear mode: electron multiplier
  • Reflectron mode: ultra fast electron multiplier

Software Functionality

  • LC-MALDI acquisition software for proteomics
  • MALDI imaging software for tissue imaging
  • Calculator for determining theoretical masses
  • Software for automatic setting of the precursor ion gate and acquisition of MS/MS spectra
  • Tools to generate peak lists and access internet or intranet protein database search engines (Mascot® from Matrix Science)

Performance Data

  • Mass range Linear – 1 - 500 kDa
  • Reflectron – 1 - 70 kDa
  • Mass resolution:
Linear – 6000 FWHM
Reflectron – 25 000 FWHM
MS/MS – 10 000 FWHM
  • Ion gate resolution – 500 FWHM
  •  Sensitivity :
Linear (peptide) – 100 amol (on target)
Linear (protein) – 100 fmol (on target)
Reflectron – 100 amol (on target)
MS/MS – 500 amol (on target)
  • Accuracy
Linear – 20 ppm with internal calibration– 100 ppm with external calibration
Reflectron – 2 ppm with internal calibration– 20 ppm with external calibration*
  • MS/MS – 50 ppm

  • Food Safety and Environmental Analysis- Shimadzu Journal Cilt 1 Sayı 1

    Food Safety and Environmental Analysis: This issue focuses on food safety and environmental analysis, and contains information on two collaborations including an interview with Professor Mondello, working on Comprehensive GC x GC / LC technology and a technical note on multi-residue analysis of pesticides in food, a collaborative work with the Food and Environment Research Agency, UK. As well as the latest news and applications.

  • Pharmaceutical Analysis and more - Shimadzu Journal Vol. 3

    • Insights from our customer Professor Alexander Arnold from the Milwaukee Institute for Drug Discovery at the University of Wisconsin-Milwaukee
    • The collaboration with Mitsubishi Tanabe Pharma Corporation, Japan for development of pharmaceutical products using Imaging Mass Spectrometry: iMScope TRIO
    • Metabolic Studies of Drug Candidates for Neurological Disorders and Asthma Based on GABAA Receptor Subtype Selective Ligands using Mass Spectrometry
    • Utility of High-resolution MALDI imaging in Drug Discovery: Histological Distribution of Gentamicin in Proximal Renal Tubules of Rats
    • And many more ...

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