Shimadzu Corporation

Nexera X2 Modular UHPLC System Dual pump, 4 gradients, 1300 bar

Nexera X2 flexible UHPLC system design achieves a true fusion between UPLC (Ultra High Pressure HPLC or Ultra High Performance HPLC) and HPLC technologies, enabling the Nexera X2 to be used for a much broader range of applications. This completely new UHPLC system not only offers maximum speed, sensitivity, resolution, stability, and reliability. it also features a revolutionary i-PDeA separation technology and an i-DReC function that extends the dynamic range so that both concentrated and trace components can be quantitated simultaneously.

The Nexera X2 offers both UHPLC and HPLC capabilities with a single system. Basic Nexera Quaternary system configurations with one solvent delivery unit are capable of gradient analysis using up to four solvents. Furthermore, existing HPLC methods can not only be reproduced on the system, but also migrated to UHPLC methods.

  • System enables to work with 1300 Bar back-pressure. 
  • The Nexera Quaternary system is able to deliver low-pressure gradient mixtures of four solvents. Its ability to load up to four types of mobile phases in a single solvent delivery unit eliminates the time and trouble of exchanging mobile phases during method development. If a low-pressure gradient unit is added to a system with two solvent delivery units, then both binary and quaternary capabilities can be achieved in a single system, which can help improve instrument utilization efficiency.
  • Nexera X2 series autosamplers are carefully designed to reduce carryover in increasingly high-sensitivity analytical applications, with features such as a multi-rinse mechanism, included as standard, that allows you to select from multiple types of solvents. They also offer high accuracy at the injection volumes optimal for column sizes typically used in UHPLC aplications.
  • Nexera X2 series autosamplers enable highly accurate analysis even at injection volumes below 1 μL. For UHPLC analysis using small columns, the optimal injection volumes are correspondingly small as well. Especially when using sample solvents with a high elution strength, it is difficult to increase the injection volume. Normally, that means samples must be diluted to reduce the effects of the sample solvents.
    Nexera X2 series autosamplers are capable of highly accurate micro volume injection, allowing even samples with high organic solvent concentrations after pretreatment to be injected directly without dilution.
  • The Nexera X2 SIL-30AC autosampler is also capable of automating pre-column derivatization reactions. Because reaction times and reagent amounts added can be kept constant, it enables highly reproducible derivatization reactions. In addition, automating the process eliminates the time and trouble of derivatization.
  • The Nexera X2 systems feature microreactor type gradient mixers that are able to mix small quantities of mobile phases with high efficiency. In addition to a 20 μL mixer that is ideal for MS front-end LC units and a 180 μL mixer that offers maximum mixing efficiency, 40 μL and 100 μL models are also available that these provide a balance between mixing performance and gradient delay, allowing you to select an optimal capacity.
  • While the SR-Cell (sensitivity and resolution cell) used in the PDA detector, has an optical path length of 10 mm, it features low-dispersion specifications. It achieves sharper peaks in UHPLC analysis while remaining just as easy to use for HPLC as before, and can be used for a wide range of applications from UHPLC to HPLC. While the optional high-sensitivity cell features an optical path length of 85 mm, the noise level is kept to a minimum.

  • Ultra-Sensitive and Rapid Assay of Neonicotinoids, Fipronil and Some Metabolites in Honey by UHPLC-MS/MS [LCMS-8060]

    Fipronil, a pesticide, has been banned by European Food Security Authoritiy (EFSA) for maize seed treatment due to its high risk for honeybee health. In order to better understand the effect of these compounds on bees and their contamination in pollen and honey, a highly sensitive assay method was necessary. A method was set up using LCMSMS.

    Instrument: Shimadzu Nexera X2 with LCMS-8060 (LCMSMS)


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