Quantitative Analysis of 57 Fragrance Allergens in Cosmetics Using Twin Line MS System

Under the European Cosmetics Directive (EC 1223/2009)1), 24 of the fragrances used in cosmetics are regulated as fragrance
allergens. If a leave-on product contains more than 0.001 % or a rinse-off product contains more than 0.01 %, it must be labeled on the product. Recently, however, following an opinion by the Scientific Committee on Consumer Safety (SCCS), the number of regulated compounds has been scheduled to be expanded to more than 80. Therefore, manufacturers of cosmetics need to know exactly what fragrance compounds are contained in finished products orraw materials.