POROS™ Cation Exchange Resins

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Thermo Fisher Scientific

POROS™ Cation Exchange Resins

POROS™ CEX resins are designed for high dynamic binding capacity over a range of pH and conductivity conditions, thereby increasing process development flexibility and manufacturing throughput.
The particle size provides superior resolution for unprecedented impurity clearance independent of scale and flow rate.

Technical Specifications
Application Note

POROS™ 50 μm HS and XS resins are powerful cation exchange resins based on sulfopropyl functionalization, designed for purification of more essential proteins and biomolecules.

They are particularly well suited for the separation of process impurities and aggregations and are excellent choices for both capture and polishing applications. Both resins are designed for superior resolution; POROS XS provides higher dynamic binding capacity at increasing salt concentrations.

POROS™ Cation Exchange Applications

Monoclonal antibodies, bispecific antibodies and antibody-drug conjugates (ADCs)
Vaccines and virus-like particles
Viral vectors, exosomes and lipid nanoparticles

Binding capacity of POROS™ XS resin with IgG at 5% pass.
High bonding capacity is achieved under a wide range of process conditions.
Column: 0.46 cm (D) x 20 cm (L); buffer: 20 mM MES; load: 5 mg/mL IgG; flow rate: 300 cm/h.

POROS™ XS and HS resins have similar, high solubility properties. Column: 1 cm (D) x 20 cm (L); buffer
A: 20 mM MES, 25 mM NaCl pH 6.2, buffer B: 20 mM MES, 1 M NaCl pH 6.2; Elution: gradient 10% 50% buffer B, 7.5 CV; flow rate: 300 cm/hr; protein mix: chymotrypsinogen A, cytochrome C and lysozyme.

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