HyPerforma™ Single Use Mixer (S.U.M.)

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Thermo Fisher Scientific

HyPerforma™ Single Use Mixer (S.U.M.)

The Thermo Scientific™ HyPerforma™ Single-Use Mixer (S.U.M.) with Touchscreen Console provides enhanced functionality, ease of use, and efficiency. The complete HyPerforma S.U.M. system consists of a mixer tank, available in 50, 100, 200, 500, 1,000, and 2,000 L sizes with the Touchscreen Console.

The HyPerforma S.U.M. has a 5:1 turndown mixing ratio, and maintains traditional stirred-tank mixer design principles with a directly coupled motor impeller drive assembly, and a cylindrical tank with a specific heightto- diameter ratio. This allows quick turnaround times for both liquid-to-liquid mixing and powder-to-liquid mixing.

Applications

Media preparation
Final formulation steps
Buffer preparation
Large-volume mixing (up to 2,000 L)
Pooling and liquid transfer
Product suspension
Mixing and storing multiple batches
Harvest collection and bulk mixing
Viral inactivation

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Technical Specifications
Application Note

Touch Console and Controllers

The Touchscreen Console provides state-of-the-art in-process monitoring and automation capability for the HyPerforma S.U.M. Its modular design allows for an easy-to-use custom user interface. Capabilities include: agitation, pumps, pinch valves, and temperature control.
Users can easily visualize measurements from load cells, pH sensors, conductivity sensors, RTD, and pressure sensors. As an engineered-to-order product, the HyPerforma S.U.M. with Touchscreen Console can be fully integrated with either HyPerforma G3 Bioprocess Controllers, or controllers from other manufacturers—providing an open-architecture mixing solution configured to your unique requirements.

The Touchscreen Console can integrate TruBio automation software powered by Emerson’s DeltaV Distributed Control platform, enabling users to optimize data acquisition while maintaining full compliance with 21 CFR Part 11.

Key Advantages

Customized module user interface allows for superior process monitoring and automation. Modules include:

Agitation (mixing rpm)
Mass (utilization of load cell readings)
Temperature (1 or 2 RTDs)
Timer
pH (1 or 2 readings)
Conductivity (1 or 2 readings)
BPC pressure (automated BPC air fill)
Liquid pressure (Pump control based on liquid pressure in lineset)
Pump control (up to four pumps, used for fill, harvest, and bolus control
Automated and metered
Fill and harvest
Recipes (user defined process automation)
Auxiliary input

S.U.M. BioProcess Containers (BPCs)

Thermo Scientific BPCs are available for the HyPerforma S.U.M. in standard or customized configurations, with your choice of Thermo Scientific™ CX5-14 or Aegis™ 5-14 film. Thermo Scientific films have among the cleanest particulate profiles in the industry and are unsurpassed in their robustness, flexibility, and mechanical properties.
Thermo Scientific BPCs can be used for pooling and storing material for your liquid-to-liquid and powder-to-liquid bioprocess mixing applications. BPC systems come in open- and closed-top designs. Custom BPCs can accommodate a range of applications. A variety of components have been qualified to maximize design flexibility, including:

Single-use pH and pressure sensors
A variety of tubing, clamps, and connector end treatments to facilitate your specific process

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