Shimadzu Corporation

LCMS-8045 Liquid Chromatograph Triple Quadrupole Mass Spectrometer (LCMSMS)

Shimadzu's new LCMS-8045 Triple Quadrupole Liquid Chromatography Mass Spectrometer makes a difference in analytical laboratories with its unique UFMS technology.

UFMS technology not only provides higher sensitivity performance, but also enables dramatic improvements in analytical results and expansion of potential application areas with excellent data quality.

In this way, LCMS-8045 Liquid Chromatography Mass Spectrometry technology is used in many different application areas such as veterinary drugs, pesticide residues, water, forensic toxicology and bioanalysis.
  • High sensitivity for complex matrices and difficult analysis
  • Method packages (Pesticides, Forensic Tox, Veterinary, Met ID etc.)
  • Upgradeability to LCMS-8060 model

High Sensitivity and Ultra High Speed Detection

Equipped with a heated ESI probe, the LCMS-8045 has the highest sensitivity in its class. The instrument is capable of providing accurate and stable data over long periods of time. The inclusion of Shimadzu's ultra-high-speed high-voltage power supply enables the world's fastest scan speed (30,000 u/s) and polarity switching time (5 ms). High-speed acquisition benefits the laboratory by reducing run times for increased throughput, and also shortens method development time.
 

Long Term Durability and High Precision

The LCMS-8045's heated ESI probe, high temperature heating block, desolvation line, drying gas and focusing optics are designed to maximize sensitivity and minimize contamination. This means reliable data collection and continuous operation in the lab on demanding matrices such as complex biological fluids and food samples.
 

LabSolutions LCMS Software and Wide-Ranging Method Packages

LabSolutions LCMS - Liquid Chromatography Mass Spectrometry Software features an intuitive user interface, and offers the latest features designed to enhance laboratory productivity and streamline workflows. Numerous pre-configured MRM method packages are available. Predetermined LC separation conditions and MRM parameters allow analysis to be started without long hours of method development, enhancing the efficiency of your laboratory.

 


Consistent High-Sensitivity Performance
Robust Ion Source and Sample Introduction System

Shimadzu's MS interface includes a high-sensitivity heated ESI source, heated capillary sample introduction, and proprietary ion transfer optics. These design features combine to produce robust MS performance. 12,000 plasma samples were injected over 25 days (over 480 samples per day). Picogram levels of alprazolam were analyzed with an RSD of 3.42%.

Instrument Detection Limits: IDL

IDL is one measure of sensitivity for analytical instrumentation. The chromatograms below show the IDL for Reserpine and Chloramphenicol, obtained using ESI+ and ESI-, respectively. The IDL for Reserpine is 2.03 femtograms and 2.09 femtograms for Chloramphenicol.

Newly Designed Ionization Unit

Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.

 















 

Easy System Maintenance Reduces Downtime

As with Shimadzu's other triple quad systems, maintaining the LCMS-8045 is simple. Replacing the desolvation line (DL) and ESI capillary is quick and easy. 

Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability.










 

 

High Performance for a Variety of Applications

Veterinary Drugs Analysis with LCMSMS 

  • Nitrofuran metabolites in fish
Nitrofurans are a class of synthetic antibiotics. The use of nitrofurans for edible animal and fishery products is banned in many countries. The chromatogram below shows the recovery of nitrofuran metabolites from fish using the LCMS-8045. Excellent linearity and accurate quantitative results ranging from 0.05 to 20 ng/mL were obtained. The LCMS-8045 is shown to be an excellent platform for routine high-sensitivity analysis in challenging matrices.

 
 

Residual Pesticides Analysis with LCMSMS

  • Simultaneous analysis of residual pesticides in herbal supplements
Regulatory agencies worldwide provide oversight for an extensive and ever-increasing list of pesticides in order to promote food safety and protect public health. The MRM chromatogram below shows the simultaneous analysis of 153 pesticides spiked into Codonopsis pilosula at 0.01 mg/kg. Plant matrices can be very challenging due to background interferences, but the LCMS-8045 provides enough sensitivity to analyze most pesticides at the trace level of 10 parts per billion. Many pesticides methods also benefit from polarity switching, which the LCMS-8045 can accomplish in just 5 msec.









 



 

 

 




 







 

Water Quality Analysis with LCMSMS 

  • High-sensitivity analysis of 21 pharmaceuticals and personal care products in less than eight minutes
Pharmaceutical and personal care products (PPCPs) encompass a family of compounds used by individuals for health and cosmetic purposes. As populations increase, and the use of these products increases, PPCPs will become a significant threat to our water supply. The LCMS-8045 is capable of trace-level quantitation of many PPCPs without extensive sample preparation.

Bioanalysis with LCMSMS

  • High-sensitivity quantitation of Amlodipine in plasma
Amlodipine is widely utilized for the treatment of high blood pressure and angina. A high-sensitivity method for the quantitation of amlodipine in human plasma using LCMS-8045 has been developed. Appropriate linearity ranging from 0.003 to 300 ng/mL with excellent accuracy was achieved. Both interday and intraday variabilities were assessed for quality control samples. Percent RSD (Relative Standard Deviation) results were less than 5%.

LabSolutions LCMS

Shimadzu's data acquisition software provides a single point of control for LC and MS parameters. Shimadzu also provides labs with software tools to address specific lab workflows and increase productivity by incorporating critical input from customers.


Fully Automatic MRM Optimization

Optimizing quantitative parameters is faster and easier with updated software that reduces MRM optimization time by 25%.


Intuitive User Interface

A new approach helps simplify the user experience for high-throughput labs. Quick batch makes it easy to perform routine LC/MS/MS analysis and make changes to Control Panel help method development.


Automatic Calculation of Waiting Time

The optimum dwell time is automatically calculated from the number of overlapping MRM channels and the maximum cycle time, thus obtaining the required data points for the entire analysis.

 

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