High Sensitivity for Trace Quantitative Analysis
UFsensitivity™

• Heated ESI Probe

  In order to improve desolvation efficiency, the newly developed heated ESI probe combines a high-temperature gas with the nebulizer spray, assisting in the desolvation of large droplets and facilitating ionization. This development allows for high-sensitivity analysis of a wide range of target compounds.

• Excellent Reproducibility Even at Attogram (ag) Levels

  Both sensitivity and reproducibility are essential when establishing low limits of quantitation. High-precision quantitative results obtained with the LCMS-8050 in the analysis of Verapamil in blood plasma at levels between 500 ag and 50 pg are shown below. Excellent reproducibility with a % RSD of 2.77 % was obtained when analyzing just 500 ag of Verapamil. The LCMS-8050 demonstrates optimal performance for quantitative analysis of even trace components of a complex matrix

Newly Designed Ionization Unit

Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open and lift the unit.
In addition, no tools are required to remove the pins attached to the APCI and DUIS units, allowing for easy maintenance.

The LCMS-8050 combines the following technologies to provide highly accurate, high-speed performance:

• 'UFsensitivity' achieves high sensitivity performance by using the new heated ESI probe and the new UFsweeper III collision cell.
• 'UFswitching' high speed positive/negative ionization switching and high speed MRM [UF-MRM] maintains data quality and sensitivity.
• The 'UFscanning' high speed scanning speed achieves high quality mass spectra even during high speed analysis.

UF-MRM™

• High-Sensitivity & High-Speed MRM at 555 ch/sec

Detect Target Compounds at Trace-Level Concentrations Simultaneous Analysis of 29 Pesticides for Water Quality Analysis

The LCMS-8050 is capable of simultaneously acquiring 555 MRM transitions per second while maintaining accuracy and precision. Sufficient data points can be collected for quantitation ions, reference ions, and internal standard ions even in chromatographic regions with unresolved peaks. The high sensitivity of the LCMS-8050 allows for trace-level analysis, such as pesticides in drinking water, without the need for sample pre-concentration. This high sensitivity is maintained even when monitoring numerous MRM channels.

UFsweeper™ III Crash Cell

By achieving fast sweeps in sequential scans, it offers twice the CID efficiency of UFsweeper II, preserves signal density, and suppresses interference even for high-speed or simultaneous multi-component analysis. Proprietary UFsweeper III, a high-sensitivity, high-speed collision cell, provides collision-free momentum without loss of momentum. accelerates ions from the cell.

UFsweeper III high speed ion transport technology minimizes ion loss even at 0.8 millisecond dwell time. High-speed MRM migrations of up to 555 channels/second accelerate lab throughput for simultaneous multi-component analysis.

Designed for Durability and Ease of Use/Maintenance

• Maintains High Precision Even Through Difficult Consecutive Analysis

In addition to speed and precision, Shimadzu designed the LCMS-8050 for the ruggedness to meet the toughest laboratory requirements and toughest matrices.
The figure below shows the results from 1000 sequential analyzes of deproteinized blood plasma samples supplemented with alprazolam.
The LCMS-8050 provides excellent repeatability with 4.59% RSD for field results over 1000 analyses.

Simultaneous, Highly Reliable Quantitative and Qualitative Analysis
UFscanning™

• High-Sensitivity & High-Speed Scanning at 30,000 u/sec

  Simultaneous Quantitative and Qualitative Analysis Simultaneous High-Speed Screening of 12 Toxicological Drugs
  
  The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step.

• Maintain Sensitivity and Mass Accuracy Even at 30,000 u/sec

• Efficient Qualitative Analysis Using Synchronized Survey Scan

The Synchronized Survey Scan (SSS) function allows MRM acquisition to be combined with a variety of other scan modes. It is extremely useful for obtaining more detailed qualitative information on components detected during multi-analyte quantitative acquisition.

Polarity Switching Technology with No Compromise in Quality or Sensitivity
UFswitching™

• High-Sensitivity & High-Speed Positive/Negative Ionization Switching in 5 msec

  Just One Minute per Analysis
  A Case Study Using High-Speed Positive/Negative Ionization Switching

  When performing simultaneous positive/negative ion measurements of multiple components, the proper acquisition of sharp UHPLC peaks depends on rapid polarity switching. The LCMS-8050 minimizes losses due to polarity switching and ensures the collection of sufficient data points for even the narrow peaks obtained with UHPLC, recording accurate peak shapes and allowing excellent reproducibility.

• Only 5 msec to Achieve Stable Quantitative Accuracy with Positive/Negative Ionization Switching

The LCMS-8050 uses unique high-voltage power supply technology to achieve an ultra-high-speed positive/negative ionization switching time of just 5 msec. The LCMS-8050 is also the only instrument of its type to maintain ion intensity even when performing polarity switching at ultra-high speed, yielding consistent, reproducible data. Excellent quantitative results can be obtained from UHPLC peaks no more than 2-3 seconds wide, even when multiple components are eluted simultaneously.










 

• Outstanding Throughput and Quantitative Accuracy

• LabSolutions LCMS 5.6 Version

• Automatic Calculation of Waiting Time

  The optimum dwell time is automatically calculated from the number of overlapping MRM channels and the maximum cycle time, thus obtaining the required data points for the entire analysis.

• Efficient Multi-Analytical Data Analysis

  LabSolutions LCMS software includes a Data Browser that allows a user to analyze and compare multiple datasets in a single window.
  In addition, a Quantitation Scanner provides efficient quantitative processing of multiple analytes.