The LCMS-8060 Liquid Chromatography Tandem Mass Spectrometer is the top model among the UFMS series triple quadrupole mass spectrometer systems, in which Shimadzu's patented UF Technologies are used to achieve the world's highest sensitivity and speed values.
The LCMS-8060 has an optimized ion guide and new technologies incorporated into the ion transport optical system.
It detects ultra-trace components in complex matrices that were difficult to detect until now, both quickly and with high sensitivity. This contributes to further improvement in data quality in any trace quantitative analysis application that requires the highest level of precision, such as biological samples.
By redefining the ion focusing capability on the UF-Qarray, the LCMS-8060 brings a meaningful impact to quantitative detection and opens new opportunities for scientists to deliver solutions that make a true difference.
The newly developed UF-Qarray ion guide is a groundbreaking technology that increases LC/MS/MS sensitivity by enhancing ion signal intensity and reducing noise. By improving the ion sampling device, the ion guide, and the vacuum efficiency, the LCMS-8060 delivers a new vision of sensitivity and makes a real difference to working better and faster.
Inspired by the need to balance advanced high speed MS/MS detection technologies with unrivalled LC performance, we were the first mass spectrometry company in the world to deliver a scan speed of 15,000 u/sec and a polarity switching speed of 15 msec. In the LCMS-8060 the scan speed is now increased to 30,000 u/sec and a polarity switching speed of 5 msec making a real difference to working better and faster.
The LCMS-8060 uses UF Technologies to switch polarity in 5 msec.
Fast cycle time helps to detect more compounds with greater confidence and precision.
Faster polarity switching time maximizes dwell times and helps to optimize the cycle time of LC/MS/MS methods.
Comparing the differed polarity switching times from 5, 20 to 50 msec. Ratio of dwell time (blue), pause time (red) and polarity switching time (green) in 400 msec of loop time when 65 of MRMs are simultaneously monitored.
In clinical research, plasma catecholamines and their O-methylated metabolites (metanephrines) are measured as biomarkers for diseases such as hypertension, pheochromocytoma or neuroblastoma.
It is a challenging assay as the low physiological levels of CAs, physicochemical properties, and potential interferences require high sensitivity and specificity.
We developed a SPE-LC/MS/MS assay by using LCMS-8060 to detect catecholamines at ultra-high sensitivity without matrix interferences. As the measurement cycle time was 12 mins including the column re-equilibration the LCMS-8060 assay opens new possibilities for multiplexed sample analysis and higher sample throughput.
Detection of Norepinephrine, Epinephrine and Dopamine and their deuterated internal standards in plasma
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