The ever increasing amount of process data generated by more sensors in smaller parallel bioreactor systems needs advanced bioprocess software to turn this data into useful information. Lucullus PIMS offers a new dimension in data processing.
Data management and data analysis is key for the future of R&D and process development in pharmaceutical industry. Lucullus PIMS bioreactor software allows the user to monitor and control bioprocesses and offers an extensive toolbox for analyzing process data c ross platforms.
Process information can be generated based on data generated in different brands of bioreactor types and wide range of different cultivation volumes.
The combination of the software with the broad range of Applikon Bioreactor Systems offer the user a unique system for validatable fast track development and basic research.

Features

• Functionality for Design of Experiments, Reactor Planning, Media Preparation and Tracking, Parallel Processing, SCADA, Data Mining and Batch Reporting
• Validatable fast track development and basic research
• Advanced software to turn this data into useful information
• Data management & data analysis

Idea & Recipe

Make your process idea come true with an intuitive tool to create your process control strategy (recipe)

• Define a Step Chain, which is a programming language, based on the user process that allows the user to define different flows of execution with looping, branching and computation of variables.
• Specifying the reactor and devices to be used in the recipe.
• Integrate alarms in the recipe ( Notification, Email, and SMS alarms)

Planning

Define everything in advance with an intuitive workflow to start the processes later with minimal effort

• Plan recipes using an intuitive workflow
• Define process parameters by integrating the design of your experiment (as well as DOE)
• Schedule and allocate bioreactors in the labs (Calendar)
• Manage samples efficiently (apply sampling strategies, define methods and prepare tubes, for instance by printing labels)
• Sample interactively during execution (reminder, information, exact timing of stamps/volumes)
• Retrieve data automatically from at-line analyzers using barcodes (E.g. Vicell, Nova pHOx, Nova Flex and etc.)  
• Assign media/feeds to be used and initiate preparation process

Preparation

Media preparation, storage and component trace-ability and media optimization

• Exercise advanced management of compound and ingredient storage
• Create Lots from recipes (generate and print barcode label)
• Monitor usage of compounds from storage
• Automate the media kitchen (pH meter, scales, etc.)
• Select Lots at process start (use barcode scanner)
• Optimize media

Execution

Execute and monitor operations which were previously defined in earlier steps

• Run a process based on a recipe or a planned process
• Facilitate the simultaneous launch and monitoring of several bioreactors
• Log data from a single and multiple bioreactors in parallel
• Store process data permanently
• Compare different processes simultaneously
• Evaluate running processes via graphs and tables
• Create a visualization of the hardware and its port configuration (PnI Diagram)

Evaluation

Turn data into useful information with a wide range of evaluation components

• Visualize data extracted from the database holding historical data
• Create and export graphs and tables
• Define an evaluation sequence
• Compare different processes with overlay graphs
• Evaluate processes using graphs and tables
• Generate batch reports automatically

Lucullus PIMS Architecture

Stand-alone Edition

The stand-alone edition is used for up to 8 different bioreactors or one multi-bioreactor system on one computer. Data is stored in a local Oracle database and access to the process data can be through the local computer or via a remote network link to this process computer. Interactions to the process can be done through the local computer in the laboratory. It is advised to use a data safety system on the local computer to make sure your valuable process data are secured in case of computer hardware failures.

Client Server Edition

The Client-Server edition is used for larger installations of Lucullus, where different labs are using the software. This distributed architecture allows the data to be stored in a safe location while the front end user interfaces are located near the bioreactors where they need to be.
Data can be reviewed in the offices by a direct link to the data server in the network. Data from different laboratories can be compared and can be used for process control or for reporting and making decisions on the path for further process development.

Lucullus PIMS

Enterprise Edition

For even larger installations with Lucullus installations at different site (even in different countries) the Enterprise edition can be
used. This version connects different installations of Lucullus and allows in the fly conversion and translation of process data. When authorized the user can view and compare data between different sites. This could be a production site and a process development site, or could even be different development sites in different locations working on the same process.