Configurations for microbial and cell culture bundles

The microbial MiniBio bundle is configured as follows

• pH control is achieved with variable speed peristaltic pump, which can be configured for base or acid addition
• Dissolved oxygen (DO) is controlled with air regulated by a solenoid valve and flow is set with a needle valve. 
• Temperature control is achieved using a heating blanket wrapped around the bioreactor and a cold water valve that is connected to a heat exchanger in the bioreactor.
• Foaming is reduced with a variable peristaltic speed pump with antifoam addition. 
• Mixing is provided by a stirrer with 2 rushton, vortex impellers.

The cell MiniBio bundle is configured as follows

• pH control is achieved with a fixed speed peristaltic pumps, which is configured as base and a CO₂ solenoid valve for acid addition. CO₂ Flow is set by a needle valve.
• Dissolved oxygen (DO) is controlled with air regulated by a solenoid valve and flow is set with a needle valve. 
• Temperature control is achieved using a heating blanket wrapped around the bioreactor.
• Mixing is provided by a stirrer with marine impeller

Key features

• Intelligent control: The controller adaptively controls all key process parameters using an autotuning feature that automatically sets optimal PID control settings.  This feature ensures that optimal control performance is achieved quickly and without the need for advanced engineering expertise.
• Access security: Password controlled access is provided for three levels of operator: operator, engineer and service engineer.  Each level has access to defined areas of functionality.
• Software update: Updating software to the latest version is extremely simple and is achieved by connecting a USB memory stick to the controller.  The system automatically loads the update.
• Advanced interface: Ethernet communication is used to connect the controller to a computer or network.  Communication to SCADA software (supervisory control and data acquisition) such as BioXpert is via Ethernet. The my-Control is OPC compliant which makes communication possible with any SCADA that meets this standard.
• Remote communication: The biocontroller can be accessed remotely via the internet using standard Internet browsers to view and control the system.
• Expandability: The my-Control can be configured to control virtually any bioprocess. Additional I/O (4x Analog In, 4x Analog Out, 8x Digital Out)or USB drivers (for scales or buglab) can be provided to communicate with external devices such as biomass monitors, optical density sensors, scales, gas analyzers, variable or fixed speed pump.
• Documentation and validation: The my-Control has been developed and documented in compliance with regulations GAMP 5. This supports the full validation of the system for your process