POROS™ AEX resins are 50 μm, rigid, polymeric, ion‑exchange chromatography resins that can be used for the chromatography of biomolecules including recombinant proteins, monoclonal antibodies, DNA, viruses, and peptides.
The resin backbone consists of cross-linked poly[styrene divinylbenzene]. A polyhydroxyl surface coating provides low nonspecific binding and different surface chemistries to provide four anion exchanger resins that are unique to the market.
















Thermo Scientific™ POROS™ ion exchange (IEX) resins are the industry standard for large scale lacquer chromatography applications.

POROS™ IEX resins allow target molecule binding and impurity removal over a wide range of process conditions, thus increasing process flexibility and production efficiency.

POROS™ Anion Exchange Applications

• Monoclonal antibodies, bispecific antibodies and antibody-drug conjugates (ADCs)
• Enzymes, hormones and blood products
• Vaccines, viral vector plasmids and oligonucleotides
• Viral vector polishing
• Excellent DNA clearance in flow mode

The dynamic binding capacity of POROS™ XQ resin with BSA at 5% pass is shown as a function of pH and salt concentration.

High capacity is achieved in a wide variety of process conditions.
Orange, red and dark red areas indicate conditions under which a BSA binding capacity of more than 100 mg/mL can be achieved.
Column: 0.46 cm(D) x 20 cm(L); load: 10 mg/mL BSA; base buffer: 20 mM Bis-Tris propane; flow rate: 300 cm/h.



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